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  <element id="opht_ResearchAndDevelopmentActivitiesMember" name="ResearchAndDevelopmentActivitiesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="opht_ResearchAndDevelopmentArrangementAggregateAmountReceivableUponAchievementOfMilestone" name="ResearchAndDevelopmentArrangementAggregateAmountReceivableUponAchievementOfMilestone" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="opht_AccruedResearchAndDevelopment" name="AccruedResearchAndDevelopment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="opht_IncreaseDecreaseInAccruedResearchAndDevelopment" name="IncreaseDecreaseInAccruedResearchAndDevelopment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
