Asset Acquisition [Axis] Asset Acquisition [Axis] U.S. federal statutory income tax rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period State Current State and Local Tax Expense (Benefit) Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Net loss Net loss Net loss Net Income (Loss) Attributable to Parent Right-of-use assets, net Operating Lease, Right-of-Use Asset Available for sale securities Debt Securities, Available-for-sale, Current Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Income Statement Location [Axis] Income Statement Location [Axis] Statistical Measurement [Domain] Statistical Measurement [Domain] Schedule of Cash Proceeds From, and the Aggregate Intrinsic Value of, Stock Options Exercised Cash Proceeds Received and Tax Benefit from Share-based Payment Awards [Table Text Block] Segment and geographic information Segment Reporting, Policy [Policy Text Block] Security Exchange Name Security Exchange Name Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Expired or forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Right-of-use asset Deferred Tax Liabilities, Right-Of-Use Asset Deferred Tax Liabilities, Right-Of-Use Asset Supplemental disclosure of cash paid Supplemental Disclosure of Cash Paid [Abstract] Operating lease, weighted average remaining lease term Operating Lease, Weighted Average Remaining Lease Term Foreign Currency Translation Foreign Currency Transactions and Translations Policy [Policy Text Block] Other assets Other Assets, Noncurrent Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Number of shares of common stock available for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Expected dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Retirement Benefits [Abstract] Retirement Benefits [Abstract] Net change in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Entity File Number Entity File Number Expected common stock price volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Share-based compensation APIC, Share-based Payment Arrangement, Increase for Cost Recognition Accrued research and development expenses Accrued Research and Development Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer) for research and development related activities. Aggregate intrinsic value of options exercised Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value Expired or forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period University of Florida Research Foundation (UFRF) University of Florida Research Foundation (UFRF) [Member] University of Florida Research Foundation (UFRF) [Member] Schedule of Available-for-Sale Securities Debt Securities, Available-for-sale [Table Text Block] Exercise prices, low end of range (in dollars per share) Share-based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit Subsequent Event Type [Domain] Subsequent Event Type [Domain] Primary Licensed Product Primary Licensed Product [Member] Primary Licensed Product [Member] Cash, Cash Equivalents and Available for Sale Securities Investments in Debt and Equity Instruments, Cash and Cash Equivalents, Unrealized and Realized Gains (Losses) [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Number of product candidates in preclinical development Number Of Product Candidates In Preclinical Development Number Of Product Candidates In Preclinical Development Gross amount of increases in unrecognized tax benefits during the period - prior year provisions Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions Net deferred tax assets Deferred Tax Assets, Net $8.08-$15.00 Exercise Price Range Four [Member] Represents information pertaining to the exercise price range four. Weighted average estimated incremental borrowing rate Operating Lease, Weighted Average Discount Rate, Percent Total (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Research and development Research and Development Expense [Member] Sale of Stock [Axis] Sale of Stock [Axis] Private Placement Private Placement [Member] Awarded (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Total fair value vested Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value Title of Individual [Domain] Title of Individual [Domain] Maturities of marketable securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Litigation stay period Litigation Stay Period Litigation Stay Period Award Type [Domain] Award Type [Domain] Exercise Price Range [Axis] Exercise Price Range [Axis] Local Phone Number Local Phone Number Assets Assets [Abstract] Options exercisable at end of year (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Weighted-average exercise price of options (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Awarded (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Preferred stock—$0.001 par value, 5,000,000 shares authorized, no shares issued or outstanding Preferred Stock, Value, Issued Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Outstanding at beginning of year (in shares) Outstanding at end of year (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Accumulated Deficit Retained Earnings [Member] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Change in working capital Increase (Decrease) in Working Capital Increase (Decrease) in Working Capital Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Sustained delivery applications Sustained Delivery Applications [Member] Sustained Delivery Applications [Member] Operating right-of-use assets obtained in exchange for lease obligations Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Schedule of Significant Components of the Company's Deferred Tax Assets (Liabilities) Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Property and equipment Property and Equipment Property, Plant and Equipment [Line Items] Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Number of operating segments Number of Operating Segments Share-Based Compensation Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Basic (in dollars per share) Net income (loss) per common share - basic (in dollars per share) Earnings Per Share, Basic Operating lease rent expense Operating Lease, Expense 2024 Lessee, Operating Lease, Liability, to be Paid, Year Three Available for Sale Securities Credit Loss, Financial Instrument [Policy Text Block] Outstanding, beginning of period (in shares) Outstanding, end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Defined contribution plan, cost recognized Defined Contribution Plan, Cost Amortization of premium and discounts on investment securities Investment Income, Net, Amortization of Discount and Premium Restricted Stock Units Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Computer, software and other office equipment Computer, Software, and Other Office Equipment [Member] Computer, Software, and Other Office Equipment [Member] Payments for license fees Payments For License Fees Payments for License Fees Cash paid from operating cash flows Operating Lease, Payments Number of shares reserved for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Research and Development Research and Development Expense, Policy [Policy Text Block] Document And Entity Information Document And Entity Information Entity Voluntary Filers Entity Voluntary Filers Plan Name [Axis] Plan Name [Axis] Quoted prices in active markets for identical assets (Level 1) Fair Value, Inputs, Level 1 [Member] Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Archemix Archemix Corp [Member] Represents information pertaining to Archemix Corp. Entity Small Business Entity Small Business Gross amount of increases in unrecognized tax benefits during the period - current year provisions Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product [Member] Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product [Member] Total liabilities and stockholders' equity Liabilities and Equity First indication First Indication [Member] First Indication [Member] Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Additional paid-in capital Additional Paid in Capital Cash equivalents Cash Equivalents, at Carrying Value Milestone Events [Axis] Milestone Events [Axis] Information pertaining to milestone events. Liabilities and Stockholders' Equity Liabilities and Equity [Abstract] Transfer of assets from Level 1 to Level 2 of the fair value measurement hierarchy Fair Value, Assets, Level 1 to Level 2 Transfers, Amount Prepaid expense and other assets Increase (Decrease) in Prepaid Expense and Other Current Assets The increase (decrease) during the reporting period in the value of prepaid expenses and other current assets not separately disclosed in the statement of cash flows. Weighted Average Exercise Price (in dollars per share) Share-based Payment Arrangement, Option, Exercise Price Range, Exercisable, Weighted Average Exercise Price Accounts payable and accrued expenses Accounts Payable and Accrued Liabilities, Current Operating Activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Net Income (Loss) Per Common Share Earnings Per Share [Text Block] Operating expenses: Operating Expenses [Abstract] Entity Interactive Data Current Entity Interactive Data Current Research and development credit Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent Decreases due to settlement with tax authorities during the period Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities Minimum Minimum [Member] Income tax receivable Income Taxes Receivable, Current 2023 Lessee, Operating Lease, Liability, to be Paid, Year Two Auditor Information [Abstract] Auditor Information Expired or forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Other comprehensive income Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Opening balance Closing Balance Unrecognized Tax Benefits Proceeds from sale of assets Proceeds from Sale of Productive Assets Income Tax Authority [Domain] Income Tax Authority [Domain] Deferred income tax assets Deferred Tax Assets, Gross Entity Common Stock, Shares Outstanding (in shares) Entity Common Stock, Shares Outstanding Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Entity Address, State or Province Entity Address, State or Province Supranational securities Supranational Securities [Member] Supranational Securities Issuance of common stock in connection with license acquisition Stock Issued During Period, Value, Acquisitions Current liabilities Liabilities, Current [Abstract] Issuance of common stock and pre-funded warrants, net Stock Issued During Period, Value, New Issues General and administrative General and Administrative Expense Proceeds from income tax refunds Proceeds from Income Tax Refunds Schedule of Components of Income Tax (Benefit) Expense Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Number Exercisable (in shares) Share-based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable Stock-Based Compensation and Compensation Plans Share-based Payment Arrangement [Text Block] Significant unobservable inputs (Level 3) Fair Value, Inputs, Level 3 [Member] Leases Lessee, Leases [Policy Text Block] Accounting Policies [Abstract] Accounting Policies [Abstract] Payments of stock issuance costs Payments of Stock Issuance Costs Issuance of common stock and pre-funded warrants, net (in shares) Stock Issued During Period, Shares, New Issues Number of reporting segments Number of Reportable Segments Present value of minimum lease payments Operating Lease, Liability Federal Current Federal Tax Expense (Benefit) Document Transition Report Document Transition Report Common stock—0.001 par value, 200,000,000 shares authorized, 115,277,012 and 90,120,797 shares issued and outstanding at December 31, 2021 and December 31, 2020, respectively Common Stock, Value, Issued RSUs expected to vest (in shares) Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest The number of equity-based payment instruments, excluding stock (or unit) options, that are expected to vest in the future as of the reporting date. Expected weighted average period to recognize share-based compensation costs Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Outstanding, beginning of period (in dollars per share) Outstanding, end of period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Operating Leases Lessee, Operating Leases [Text Block] Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Entity Emerging Growth Company Entity Emerging Growth Company Underwritten Offering, Underwriters Underwritten Offering, Underwriters [Member] Underwritten Offering, Underwriters Restricted stock units Restricted Stock [Member] Milestone Events [Domain] Milestone Events [Domain] Represents the types of milestone events. ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Gross amount of decreases in unrecognized tax benefits during the period - other Unrecognized Tax Benefits, Other Increase (Decrease) Unrecognized Tax Benefits, Other Increase (Decrease) Schedule of Weighted-average Aassumptions Used to Estimate Grant Date Fair Value of Stock Options Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value [Abstract] 2019 Inducement Plan Two Thousand Nineteen Inducement Plan [Member] Two Thousand Nineteen Inducement Plan [Member] Achievement of specified commercial milestones Achievement Of Specified Commercial Milestones [Member] Represents information pertaining to the achievement of specified commercial milestones. Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Shares issued for license fees (in shares) Shares Issued For License Fees Shares Issued For License Fees Auditor Name Auditor Name Class of Stock [Axis] Class of Stock [Axis] Number of licensed products Number Of Licensed Products Number of Licensed Products Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Pre-funded warrants outstanding (in shares) Class of Warrant or Right, Outstanding Less imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Cash, Cash Equivalents, and Short-term Investments [Abstract] Schedule of Position With Respect to Uncertain Tax Positions Summary of Income Tax Contingencies [Table Text Block] Schedule of Commitments and Contingencies [Line Items] Schedule of Commitments and Contingencies [Line Items] Schedule of Commitments and Contingencies [Line Items] Income Tax Authority [Axis] Income Tax Authority [Axis] Proceeds from employee stock plan purchases and stock option exercises Proceeds From Stock Options And Warrants Exercised The cash inflow from associated with the amount received from holders exercising their stock options and warrants. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. Cash Cash Stock-based consideration in connection with license acquisition Share-Based Payment Arrangement, Noncash Expense In Connection With License Acquisition Share-Based Payment Arrangement, Noncash Expense In Connection With License Acquisition Issuance of common stock under the excercise of pre-funded warrants Stock Issued During Period, Value, Conversion of Units Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Range of Exercise Prices Share-based Payment Arrangement, Option, Exercise Price Range [Line Items] Financial Instrument [Axis] Financial Instrument [Axis] Share-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Weighted Average Remaining Life (Years) Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Remaining Contractual Term Current: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] License and technology payments Deferred Tax Assets License and Technology Payments Amount before allocation of valuation allowances of deferred tax asset attributable to deductible license and technology payments. Stock options Share-based Payment Arrangement, Option [Member] Aggregate intrinsic value of RSUs expected to vest Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Expected To Vest Intrinsic value of equity-based compensation awards expected to vest. Excludes stock and unit options. Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Equity [Abstract] Equity [Abstract] Issuance of common stock under employee stock compensation plans Stock Issued During Period, Value, Issued for Services Depreciation Deferred Tax Assets, Property, Plant and Equipment Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Common Stock Common Stock [Member] Schedule of Commitments and Contingencies [Table] Schedule of Commitments and Contingencies [Table] Schedule of information pertaining to commitments and contingencies. Loss from operations Operating Income (Loss) Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Lease liability, current Less current portion Operating Lease, Liability, Current Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Licensing and Commercialization Agreements Collaborative Arrangement Disclosure [Text Block] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Document Fiscal Year Focus Document Fiscal Year Focus Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Share-based compensation Share-based Payment Arrangement, Noncash Expense Additional paid-in capital Additional Paid-in Capital [Member] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Depreciation Depreciation expense Depreciation Cash and Cash Equivalents [Abstract] Cash and Cash Equivalents [Abstract] Issuance of common stock under the excercise of pre-funded warrants (in shares) Stock Issued During Period, Shares, Conversion of Units $4.89-$8.07 Exercise Price Range Three [Member] Represents information pertaining to the exercise price range three. Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Number of warrants issued (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights Public Stock Offering Public Stock Offering [Member] Public Stock Offering [Member] Other income (expense), net Other Nonoperating Income (Expense) Licensing agreement term Licensing Agreement Term Licensing Agreement Term Purchase of property and equipment Payments to Acquire Property, Plant, and Equipment Maximum Maximum [Member] Share-based Payment Arrangement [Abstract] Share-based Payment Arrangement [Abstract] Percent of pre-tax income: Effective Income Tax Rate Reconciliation, Percent [Abstract] Total liabilities Liabilities Award Type [Axis] Award Type [Axis] Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Aggregate Intrinsic Value of Options Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Schedule of Operating Lease Liability Maturities Lessee, Operating Lease, Liability, Maturity [Table Text Block] Total stockholders' equity Balance at beginning of period Balance at beginning of period Stockholders' Equity Attributable to Parent Settled Litigation Settled Litigation [Member] Issuance of common stock under employee stock compensation plan (in shares) Stock Issued During Period, Shares, Issued for Services 2013 Plan Stock Incentive2013 Plan [Member] Represents information pertaining to the 2013 Stock Incentive Plan. Federal net operating loss carryforwards Operating Loss Carryforwards Common stock, shares issued (in shares) Common Stock, Shares, Issued Contingent consideration Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Value, High Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Value, High Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued City Area Code City Area Code Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable and Accrued Liabilities Aggregate Intrinsic Value of Options Exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Wet AMD Wet AMD Product [Member] Wet AMD Product [Member] Future minimum rental commitments under non-cancelable operating leases Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] Amount to be paid on achievement of milestone Amount to be Paid On Achievement of Milestone Represents the amount to be paid by the entity on achievement of various milestones. Entity Address, City or Town Entity Address, City or Town Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Estimated useful lives Useful life Property, Plant and Equipment, Useful Life Stockholders' equity Stockholders' Equity Attributable to Parent [Abstract] Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Risk-free interest rate, minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Lease liability, non-current Total long-term operating lease liabilities Operating Lease, Liability, Noncurrent Measurement Frequency [Domain] Measurement Frequency [Domain] Deferred: Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] Options Outstanding Share Based Compensation, Shares Authorized under Stock Option Plans Exercise Price Range Options Outstanding [Abstract] Employees Employees [Member] Represents information pertaining to the employees. Accumulated deficit Retained Earnings (Accumulated Deficit) Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Entity Filer Category Entity Filer Category U.S. Treasury securities US Treasury Securities [Member] Income Statement [Abstract] Income Statement [Abstract] Contingently issuable shares, asset acquisition (in shares) Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Shares Issuable, High Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Shares Issuable, High Entity Registrant Name Entity Registrant Name Deferred tax assets (liabilities) Components of Deferred Tax Assets and Liabilities [Abstract] miniCEP290 miniCEP290 [Member] miniCEP290 [Member] Trial data period Trial Data Period Trial Data Period Cash proceeds from options exercised Proceeds from Stock Options Exercised Summary of Significant Accounting Policies Basis of Presentation and Significant Accounting Policies [Text Block] Weighted Average Exercise Price (in dollars per share) Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price Income tax benefit Income tax benefit Income tax benefit Income Tax Expense (Benefit) Amendment Flag Amendment Flag Equity Components [Axis] Equity Components [Axis] Entity Tax Identification Number Entity Tax Identification Number Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Document Fiscal Period Focus Document Fiscal Period Focus Total current assets Assets, Current Summary of the Stock Options Outstanding and Exercisable Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block] Total minimum lease payments Lessee, Operating Lease, Liability, to be Paid Sale of Stock [Domain] Sale of Stock [Domain] Expired or forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Accrued interest receivable Increase (Decrease) in Accrued Interest Receivable, Net Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Inception 4 Inception 4 [Member] Inception 4 [Member] Share-Based Compensation Share-based Payment Arrangement [Policy Text Block] Federal Deferred Federal Income Tax Expense (Benefit) Fair Value Measurements Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Cash, cash equivalents and available for sale securities Cash And Cash Equivalents And Debt Securities Available For Sale Cash And Cash Equivalents And Debt Securities Available For Sale Unrecognized share-based compensation costs for option awards, net of estimated forfeitures Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Product and Service [Axis] Product and Service [Axis] Property, Plant and Equipment, Type [Domain] Long-Lived Tangible Asset [Domain] Financing Activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Entity Public Float Entity Public Float Documents Incorporated by Reference Documents Incorporated by Reference [Text Block] Unrecognized compensation costs, net of estimated forfeitures Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount Concentration of Suppliers Concentration of Suppliers Policy, [Policy Text Block] Disclosure of accounting policy for concentration of suppliers. Weighted average grant date fair value (per share) of options granted during the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Equity Component [Domain] Equity Component [Domain] 2022 Lessee, Operating Lease, Liability, to be Paid, Year One Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Common stock issued (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Statement [Line Items] Statement [Line Items] Issuance of common stock in connection with license acquisition (in shares) Stock Issued During Period, Shares, Acquisitions Accrued expenses Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] University Of Massachusetts (UMass) University Of Massachusetts (UMass) [Member] University Of Massachusetts (UMass) [Member] Domestic Tax Authority Domestic Tax Authority [Member] Series B Preferred Stock Series B Preferred Stock [Member] Available for sale debt securities Fair Value Debt Securities, Available-for-sale Change in valuation allowance Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent Counterparty Name [Domain] Counterparty Name [Domain] Fair Value Measurements Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block] Purchase of marketable securities Payments to Acquire Marketable Securities Purchase price of common stock as percentage of fair market value Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent Loss before income tax benefit Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Significant other observable inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Property, Plant and Equipment, Type [Axis] Long-Lived Tangible Asset [Axis] Valuation allowance Deferred Tax Assets, Valuation Allowance Auditor Location Auditor Location Amortized Cost Debt Securities, Available-for-sale, Amortized Cost Employee Benefit Plan Retirement Benefits [Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Schedule of Computation of Basic and Diluted Net Income (Loss) per Common Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Document Annual Report Document Annual Report Other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Schedule of Share-based Compensation Expense Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Title of 12(b) Security Title of 12(b) Security Proceeds from issuance of common stock and pre-funded warrants, net, and related to acquisition Proceeds from Issuance of Common Stock Total assets Assets Plan Name [Domain] Plan Name [Domain] Lease obligation Deferred Tax Assets, Lease Obligation Deferred Tax Assets, Lease Obligation Common stock, shares authorized (in shares) Common Stock, Shares Authorized Title of Individual [Axis] Title of Individual [Axis] Document Type Document Type Summary of the Company's Outstanding Shares of RSU Awards Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Product and Service [Domain] Product and Service [Domain] Research and development Research and Development Expense Change in unrecognized tax liability Unrecognized Tax Benefits, Period Increase (Decrease) Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Stock Option and Compensation Plans Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Measurement Frequency [Axis] Measurement Frequency [Axis] Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Share-based Payment Arrangement, Option, Exercise Price Range [Table] Share-based Payment Arrangement, Option, Exercise Price Range [Table] Litigation Status [Axis] Litigation Status [Axis] C5 Licensed Product C5 Licensed Products [Member] Represents information pertaining to C5 Licensed products as defined by the agreement. Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) [Member] University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) [Member] Permanent items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent Basic (in shares) Weighted Average Number of Shares Outstanding, Basic Dilutive (in dollars per share) Net income (loss) per common share - diluted (in dollars per share) Earnings Per Share, Diluted $2.97-$4.88 Exercise Price Range Two [Member] Represents information pertaining to the exercise price range two. Sale of stock, price per share (in dollars per share) Sale of Stock, Price Per Share Income taxes received, net Income Taxes Paid, Net Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Weighted average common shares outstanding: Weighted Average Number of Shares Outstanding, Diluted [Abstract] University Of Pennsylvania University Of Pennsylvania [Member] University Of Pennsylvania [Member] Corporate debt securities Corporate Debt Securities [Member] Schedule of Reconciliation of the Statutory U.S. Federal Rate to the Company's Effective Tax Rate Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Clinical and marketing approval milestones Asset Acquisition, Clinical And Marketing Approval Milestones Asset Acquisition, Clinical And Marketing Approval Milestones Impact of state rate changes Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Financial Instrument [Domain] Financial Instruments [Domain] Document Period End Date Document Period End Date Unusual or Infrequent Item, or Both [Domain] Unusual or Infrequent Item, or Both [Domain] Entity Central Index Key Entity Central Index Key Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Unrealized gain (loss) on available-for-sale securities, net of tax Supplemental disclosures of non-cash information related to investing activities OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax Common Stock Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] 2007 Plan Stock Incentive2007 Plan [Member] Represents information pertaining to the 2007 Stock Incentive Plan. State Deferred State and Local Income Tax Expense (Benefit) State taxes, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Investing Activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Research and development credits Deferred Tax Assets, Tax Credit Carryforwards, Research Income Statement Location [Domain] Income Statement Location [Domain] Exercise prices, high end of range (in dollars per share) Share-based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Supplemental disclosures of non-cash information related to investing activities Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Underwritten Offering Underwritten Offering [Member] Underwritten Offering Increase in number of shares available under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Withholding period Offering period Share-Based Compensation Arrangements By Share-based Payment Award, Withholding Period Share-Based Compensation Arrangements By Share-based Payment Award, Withholding Period Specified Commercial Sales Milestones Related to a Licensed Product Specified Commercial Sales Milestones Related to a Licensed Product [Member] Specified Commercial Sales Milestones Related to a Licensed Product [Member] CARES Act CARES Act [Member] CARES Act [Member] Loss Contingencies [Line Items] Loss Contingencies [Line Items] Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Total operating expenses Operating Expenses Adeno-Associated Virus Mediated Gene Therapy Program Adeno-Associated Virus Mediated Gene Therapy Program [Member] Adeno-Associated Virus Mediated Gene Therapy Program Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Trading Symbol Trading Symbol Earnings Per Share [Abstract] Earnings Per Share [Abstract] Weighted-average fair value of RSUs expected to vest (in dollars per share) Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value Represents the weighted average fair value of equity awards, other than options, that are expected to vest as of the reporting date. Property and equipment, gross Property, Plant and Equipment, Gross Other assets Increase (Decrease) in Other Operating Assets Research, manufacturing and clinical equipment Equipment [Member] Warrant price (USD per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Options outstanding (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Outstanding at beginning of year (in dollars per share) Outstanding at end of year (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Asset Acquisition [Domain] Asset Acquisition [Domain] Achievement of specified clinical and regulatory milestones Achievement Of Specified Clinical And Regulatory Milestones [Member] Represents information pertaining to the achievement of specified clinical and regulatory milestones. Share-based compensation expense Share-based Payment Arrangement, Expense Unusual or Infrequent Item, or Both [Axis] Unusual or Infrequent Item, or Both [Axis] Entity Current Reporting Status Entity Current Reporting Status Net loss per common share: Basic and diluted net loss per common share calculation: Earnings Per Share, Basic and Diluted [Abstract] Weighted Average Grant-Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Settlement to be paid Loss Contingency, Estimate of Possible Loss Series A Preferred Stock Series A Preferred Stock [Member] GA GA Product [Member] GA Product [Member] Federal and state net operating loss carryforwards Deferred Tax Assets Operating Loss Carryforwards Federal State And Local Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards, including federal, state and local operating loss carryforwards. Stock options outstanding Employee And Nonemployee Stock Option [Member] An arrangement whereby an employee and non-employees are entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Although there are variations, normally, after vesting, when an option is exercised, the holder pays the strike value in cash to the issuing employer-entity and receives equity shares. The equity shares can be sold into the market for cash at the current market price without restriction. Options may be used to attract, retain and incentivize employees, in addition to their regular salary and other benefits. $1.20-$2.96 Exercise Price Range One [Member] Represents information pertaining to the exercise price range one. Counterparty Name [Axis] Counterparty Name [Axis] Gain on sale of property and equipment Gain (Loss) on Disposition of Property Plant Equipment Beginning of period End of period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Balance at beginning of period (in shares) Balance at end of period (in shares) Shares, Issued Annual increase in shares reserved for issuance under the Plan (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Annual Increase in Shares Reserved for Issuance Represents the percentage of annual increase in the shares reserved for issuance under the equity-based compensation plan. Sale of stock, number of shares issued in transaction (in shares) Sale of Stock, Number of Shares Issued in Transaction Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Contingently issuable shares, asset acquisition, as a percentage of total shares outstanding Asset Acquisition, Contingent Consideration Arrangements, Contingently Issuable Shares As A Percentage Of Shares Outstanding Asset Acquisition, Contingent Consideration Arrangements, Contingently Issuable Shares As A Percentage Of Shares Outstanding Risk-free interest rate, maximum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Current assets Assets, Current [Abstract] Agreement Research and Development Arrangement, Contract to Perform for Others [Line Items] Interest income Interest Income (Expense), Nonoperating, Net Leases [Abstract] Leases [Abstract] Private Placement, Underwriters Private Placement, Underwriters [Member] Private Placement, Underwriters Income Taxes Income Tax, Policy [Policy Text Block] Investments in money market funds Cash and Cash Equivalents, Fair Value Disclosure Entity Address, Postal Zip Code Entity Address, Postal Zip Code Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Diluted (in shares) Weighted average common shares outstanding - dilutive Weighted Average Number of Shares Outstanding, Diluted Exercise Price Range [Domain] Exercise Price Range [Domain] Recurring basis Fair Value, Recurring [Member] Income Taxes Income Tax Disclosure [Text Block] Over-Allotment Option Over-Allotment Option [Member] Summary of the Stock Option Activity Including Weighted Average Exercise Prices, Options Outstanding and Exercisable Share-based Payment Arrangement, Option, Activity [Table Text Block] License Agreements License Agreement Terms [Member] Common Stock Stockholders' Equity Note Disclosure [Text Block] Reduction of unrecognized tax benefits due to expiration of the state of limitations during the period Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations Schedule of Potentially Dilutive Securities Excluded from the Computations of Diluted Weighted Average Common Shares Outstanding Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Financial Instruments Fair Value of Financial Instruments, Policy [Policy Text Block] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Auditor Firm ID Auditor Firm ID Class of Stock [Line Items] Class of Stock [Line Items] Entity Address, Address Line One Entity Address, Address Line One Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Second and third indication Second and Third Indication [Member] Second and Third Indication [Member] Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Other Licensed Product Other Licensed Product [Member] Other Licensed Product [Member] General and administrative General and Administrative Expense [Member] Basis of Consolidation Consolidation, Policy [Policy Text Block] Entity Shell Company Entity Shell Company Expected term of options (years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Income tax receivable Increase (Decrease) in Income Taxes Receivable Total current liabilities Liabilities, Current Class of Stock [Domain] Class of Stock [Domain] ESPP Employee Stock [Member] $15.01-$73.22 Exercise Price Range Five [Member] Represents information pertaining to the exercise price range five. Litigation Status [Domain] Litigation Status [Domain] BEST1 License Agreement BEST1 License Agreement [Member] BEST1 License Agreement [Member] Number of milestone payments Number Of Milestone Payments Number Of Milestone Payments Money market funds Money Market Funds [Member] Loss Contingencies [Table] Loss Contingencies [Table] Options, vested and expected to vest, outstanding, aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Current Fiscal Year End Date Current Fiscal Year End Date Options Exercisable Share Based Compensation Shares Authorized under Stock Option Plans Exercise Price Range Options Exercisable [Abstract] Junior Series A Preferred Stock Junior Series A Convertible Preferred Stock [Member] Represents information pertaining to junior series A preferred stock that may be exchanged into common shares or other types of securities at the owner's option. Proceeds from stock plans Proceeds from Stock Plans Statement [Table] Statement [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Asset-backed securities Asset-backed Securities [Member] Recently Adopted and Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Share price calculation base, period (in days) Asset Acquisition, Milestone Payment Share Price Basis For Calculation, Trading Days Asset Acquisition, Milestone Payment Share Price Basis For Calculation, Trading Days Other Deferred Tax Assets, Other Statistical Measurement [Axis] Statistical Measurement [Axis] Subsequent Event Subsequent Event [Member] Total Options Outstanding (in shares) Share-based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding Business Nature of Operations [Text Block] Adjustments to reconcile net loss to net cash (used in) provided by operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Accrued research and development expenses Increase Decrease in Accrued research and development Represents the increase (decrease) during the reporting period in the aggregate amount of research and development expenses incurred. Subsequent Event Type [Axis] Subsequent Event Type [Axis] Annual increase in shares reserved for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Annual Increase in Shares Reserved for Issuance Represents the number of shares which will annually increase the shares reserved for issuance under the equity-based compensation plan. RHO-adRP License Agreement RHO-adRP License Agreement [Member] RHO-adRP License Agreement [Member] Automobile Automobiles [Member] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Weighted-average remaining contractual life of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term