Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Restructuring and Related Activities [Abstract] Reconciliation of severance-related accrual activity Restructuring and Related Costs [Table Text Block] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table] Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table] Exercise Price Range [Axis] Exercise Price Range [Axis] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain] $0.12-$10.03 Exercise Price Range One [Member] Represents information pertaining to the exercise price range one. $10.04-$20.00 Exercise Price Range Two [Member] Represents information pertaining to the exercise price range two. $20.01-$30.00 Exercise Price Range Three [Member] Represents information pertaining to the exercise price range three. $30.01-$40.00 Exercise Price Range Four [Member] Represents information pertaining to the exercise price range four. $40.01-$55.00 Exercise Price Range Five [Member] Represents information pertaining to the exercise price range five. $55.01-$73.22 Exercise Price Range Six [Member] Represents information pertaining to the exercise price range six. Range of Exercise Prices Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] Options Outstanding Share Based Compensation, Shares Authorized under Stock Option Plans Exercise Price Range Options Outstanding [Abstract] Total Options Outstanding (in shares) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options Weighted Average Remaining Life (Years) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Remaining Contractual Term Weighted Average Exercise Price (in dollars per share) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Exercise Price Aggregate Intrinsic Value of Options Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Options Exercisable Share Based Compensation Shares Authorized under Stock Option Plans Exercise Price Range Options Exercisable [Abstract] Number Exercisable (in shares) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Exercisable Options Weighted Average Exercise Price (in dollars per share) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Exercisable Options, Weighted Average Exercise Price Aggregate Intrinsic Value of Options Exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Exercise prices, low end of range (in dollars per share) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Lower Range Limit Exercise prices, high end of range (in dollars per share) Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit Accounting Policies [Abstract] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Award Type [Axis] Award Type [Axis] Equity Award [Domain] Equity Award [Domain] Stock options Employee Stock Option [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Expected common stock price volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Risk-free interest rate, minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Risk-free interest rate, maximum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Expected term of options (years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Expected dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Minimum Minimum [Member] Maximum Maximum [Member] Property and equipment Property, Plant and Equipment [Line Items] Estimated useful lives Property, Plant and Equipment, Useful Life Quarterly Financial Information Disclosure [Abstract] Summary of the quarterly results of operations Quarterly Financial Information [Table Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Business Nature of Operations [Text Block] Statement of Financial Position [Abstract] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common stock, shares authorized (in shares) Common Stock, Shares Authorized Common stock, shares issued (in shares) Common Stock, Shares, Issued Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Selected Quarterly Financial Information (unaudited) Quarterly Financial Information [Text Block] Commitments and Contingencies Disclosure [Abstract] Schedule of Commitments and Contingencies [Table] Schedule of Commitments and Contingencies [Table] Schedule of information pertaining to commitments and contingencies. Asset Acquisition [Axis] Asset Acquisition [Axis] Asset Acquisition [Axis] Asset Acquisition [Domain] Asset Acquisition [Domain] [Domain] for Asset Acquisition [Axis] Inception 4 Inception 4 [Member] Inception 4 [Member] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] RHO-adRP License Agreement RHO-adRP License Agreement [Member] RHO-adRP License Agreement [Member] Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] License Agreements License Agreement Terms [Member] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Archemix Archemix Corp [Member] Represents information pertaining to Archemix Corp. University of Florida Research Foundation (UFRF) University of Florida Research Foundation (UFRF) [Member] University of Florida Research Foundation (UFRF) [Member] Product and Service [Axis] Product and Service [Axis] Product and Service [Domain] Product and Service [Domain] C5 Licensed Product C5 Licensed Products [Member] Represents information pertaining to C5 Licensed products as defined by the agreement. GA GA Product [Member] GA Product [Member] Wet AMD Wet AMD Product [Member] Wet AMD Product [Member] Milestone Events [Axis] Milestone Events [Axis] Information pertaining to milestone events. Milestone Events [Domain] Milestone Events [Domain] Represents the types of milestone events. Achievement of specified clinical and regulatory milestones Achievement Of Specified Clinical And Regulatory Milestones [Member] Represents information pertaining to the achievement of specified clinical and regulatory milestones. First indication First Indication [Member] First Indication [Member] Second and third indication Second and Third Indication [Member] Second and Third Indication [Member] Sustained delivery applications Sustained Delivery Applications [Member] Sustained Delivery Applications [Member] Achievement of specified commercial milestones Achievement Of Specified Commercial Milestones [Member] Represents information pertaining to the achievement of specified commercial milestones. Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product [Member] Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product [Member] Specified Commercial Sales Milestones Related to a Licensed Product Specified Commercial Sales Milestones Related to a Licensed Product [Member] Specified Commercial Sales Milestones Related to a Licensed Product [Member] Commitments and contingencies Commitments and Contingencies [Line Items] Amount to be paid on achievement of milestone Amount to be Paid On Achievement of Milestone Represents the amount to be paid by the entity on achievement of various milestones. Contingent consideration Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Value, High Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Value, High Clinical and marketing approval milestones Asset Acquisition, Clinical And Marketing Approval Milestones Asset Acquisition, Clinical And Marketing Approval Milestones Contingently issuable shares, asset acquisition (in shares) Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Shares Issuable, High Asset Acquisition, Contingent Consideration Arrangements, Range Of Outcomes, Shares Issuable, High Contingently issuable shares, asset acquisition, as a percentage of total shares outstanding Asset Acquisition, Contingent Consideration Arrangements, Contingently Issuable Shares As A Percentage Of Shares Outstanding Asset Acquisition, Contingent Consideration Arrangements, Contingently Issuable Shares As A Percentage Of Shares Outstanding Loss contingency estimate, plaintiff's counsel fees Loss Contingency, Estimate of Possible Loss Current: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] Federal Current Federal Tax Expense (Benefit) State Current State and Local Tax Expense (Benefit) Deferred: Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] Federal Deferred Federal Income Tax Expense (Benefit) State Deferred State and Local Income Tax Expense (Benefit) Income tax benefit Income Tax Expense (Benefit) Earnings Per Share [Abstract] Basic and diluted net loss per common share calculation: Earnings Per Share, Basic and Diluted [Abstract] Net income (loss) Net Income (Loss) Attributable to Parent Weighted average common shares outstanding - basic (in shares) Weighted Average Number of Shares Outstanding, Basic Plus: net effect of dilutive stock options and unvested restricted stock units (in shares) Weighted Average Number Diluted Shares Outstanding Adjustment Weighted average common shares outstanding - dilutive (in shares) Weighted Average Number of Shares Outstanding, Diluted Net income (loss) per common share - basic (USD per share) Earnings Per Share, Basic Net income (loss) per common share - diluted (USD per share) Earnings Per Share, Diluted Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Stock options outstanding Employee And Nonemployee Stock Option [Member] An arrangement whereby an employee and non-employees are entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Although there are variations, normally, after vesting, when an option is exercised, the holder pays the strike value in cash to the issuing employer-entity and receives equity shares. The equity shares can be sold into the market for cash at the current market price without restriction. Options may be used to attract, retain and incentivize employees, in addition to their regular salary and other benefits. Restricted stock units Restricted Stock [Member] Anti-dilutive securities Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Total (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Asset Acquisition [Abstract] Asset Acquisition [Abstract] Inception 4 Acquisition Asset Acquisition [Text Block] Asset Acquisition [Text Block] Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Basis of Consolidation Consolidation, Policy [Policy Text Block] Segment and geographic information Segment Reporting, Policy [Policy Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Business combinations and asset acquisitions Business Combinations Policy [Policy Text Block] Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Suppliers Concentration of Suppliers Policy, [Policy Text Block] Disclosure of accounting policy for concentration of suppliers. Foreign Currency Translation Foreign Currency Transactions and Translations Policy [Policy Text Block] Financial Instruments Fair Value of Financial Instruments, Policy [Policy Text Block] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Research and Development Research and Development Expense, Policy [Policy Text Block] Income Taxes Income Tax, Policy [Policy Text Block] Share-Based Compensation Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Recently Adopted and Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Leases [Abstract] Future minimum rental commitments under non-cancelable operating leases Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] 2019 Operating Leases, Future Minimum Payments Due, Next Twelve Months 2020 Operating Leases, Future Minimum Payments, Due in Two Years Total Operating Leases, Future Minimum Payments Due Rent expense Operating Leases, Rent Expense, Net Related Party Transactions [Abstract] Financing Agreement with Novo Holdings A/S Related Party Transactions Disclosure [Text Block] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Cash proceeds from options exercised Proceeds from Stock Options Exercised Aggregate intrinsic value of options exercised Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Cash and Cash Equivalents [Abstract] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Investments in money market funds Money Market Funds [Member] Investments in corporate debt securities Debt Securities [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Quoted prices in active markets for identical assets (Level 1) Fair Value, Inputs, Level 1 [Member] Significant other observable inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Significant unobservable inputs (Level 3) Fair Value, Inputs, Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Cash and cash equivalents, fair value Cash and Cash Equivalents, Fair Value Disclosure Percent of pre-tax income: Effective Income Tax Rate Reconciliation, Percent [Abstract] U.S. federal statutory income tax rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent State taxes, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Permanent items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent Remeasurement of deferred tax assets Effective Income Tax Rate Reconciliation, Tax Cuts and Jobs Act, Percent Effective Income Tax Rate Reconciliation, Tax Cuts and Jobs Act, Percent Impact of state rate changes Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent Research and development credit Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent Alternative minimum tax credit Effective Income Tax Rate Reconciliation,Other Reconciling Items, Percent Change in valuation allowance Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Schedule Of Asset Acquisition [Table] Schedule Of Asset Acquisition [Table] Schedule Of Asset Acquisition [Table] Schedule Of Asset Acquisition [Line Items] Schedule Of Asset Acquisition [Line Items] [Line Items] for Schedule Of Asset Acquisition [Table] Number of shares issued in asset acquisition (in shares) Asset Acquisition, Equity Interest Issued Or Issuable, Number Of Shares Asset Acquisition, Equity Interest Issued Or Issuable, Number Of Shares Value of shares issued in asset acquisition Asset Acquisition, Consideration Transferred, Equity Interests Issued And Issuable Asset Acquisition, Consideration Transferred, Equity Interests Issued And Issuable Share price (USD per share) Share Price Cash acquired in asset acquisition Asset Acquisition, Cash and Equivalents Asset Acquisition, Cash and Equivalents Non-cash charge on acquired in-process research and development Asset Impairment Charges Transaction costs Asset Acquisition, Transaction Costs Asset Acquisition, Transaction Costs Schedule of reconciliation of the statutory U.S. federal rate to the Company's effective tax rate Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Schedule of components of income tax (benefit) expense Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Schedule of significant components of the Company's deferred tax assets (liabilities) Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Schedule of position with respect to uncertain tax positions Summary of Income Tax Contingencies [Table Text Block] Retirement Benefits [Abstract] Defined contribution plan, cost recognized Defined Contribution Plan, Cost Restructuring Activities Restructuring and Related Activities Disclosure [Text Block] Schedule of collaboration revenue components Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block] Number of operating segments Number of Operating Segments Number of reporting segments Number of Reportable Segments Statement of Comprehensive Income [Abstract] Net loss Other comprehensive income Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Unrealized gain on available for sale securities, net of tax Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, after Tax Other comprehensive income Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Statement of Stockholders' Equity [Abstract] Statement [Table] Statement [Table] Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Junior Series A Preferred Stock Junior Series A Convertible Preferred Stock [Member] Represents information pertaining to junior series A preferred stock that may be exchanged into common shares or other types of securities at the owner's option. Common Stock Common Stock [Member] Additional paid-in capital Additional Paid-in Capital [Member] Accumulated Deficit Retained Earnings [Member] Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Statement Statement [Line Items] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Balance at beginning of period (in shares) Shares, Issued Balance at beginning of period Stockholders' Equity Attributable to Parent Issuance of common stock under employee stock compensation plans and warrants (in shares) Stock Issued During Period Shares Options And Warrants Exercised Number of shares of stock issued as a result of the exercise of stock options and warrants. Issuance of common stock under employee stock compensation plans and warrants Stock Issued During Period Value Stock Options and Warrants Exercised Value of stock issued as a result of the exercise of stock options and warrants. Issuance of common stock related to acquisition (in shares) Stock Issued During Period, Shares, Acquisitions Issuance of common stock related to acquisition Stock Issued During Period, Value, Acquisitions Share-based compensation Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Excess tax benefit from share-based compensation Adjustments to Additional Paid in Capital, Income Tax Benefit from Share-based Compensation Balance at end of period (in shares) Ending balance Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Opening balance Unrecognized Tax Benefits Gross amount of increases in unrecognized tax benefits during the period - current year provisions Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions Gross amount of increases in unrecognized tax benefits during the period - prior year provisions Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions Gross amount of decreases in unrecognized tax benefits during the period - other Unrecognized Tax Benefits, Other Increase (Decrease) Unrecognized Tax Benefits, Other Increase (Decrease) Decreases due to settlement with tax authorities during the period Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities Reduction of unrecognized tax benefits due to expiration of the state of limitations during the period Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations Closing Balance Assets Assets [Abstract] Current assets Assets, Current [Abstract] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Income tax receivable Income Taxes Receivable, Current Total current assets Assets, Current Property and equipment, net Property, Plant and Equipment, Net Income tax receivable, non-current Income Taxes Receivable, Noncurrent Deferred tax assets Deferred Income Tax Assets, Net Other assets Other Assets, Noncurrent Total assets Assets Liabilities and Stockholders' Equity Liabilities and Equity [Abstract] Current liabilities Liabilities, Current [Abstract] Accrued research and development expenses Accrued Research and Development Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer) for research and development related activities. Accounts payable and accrued expenses Accounts Payable and Accrued Liabilities, Current Total current liabilities Liabilities, Current Royalty purchase liability Royalty Guarantees, Commitments, Amount Total liabilities Liabilities Stockholders' equity Stockholders' Equity Attributable to Parent [Abstract] Preferred stock—$0.001 par value, 5,000,000 shares authorized, no shares issued or outstanding Preferred Stock, Value, Issued Common stock—$0.001 par value, 200,000,000 shares authorized, 41,397,197 and 36,110,298 shares issued and outstanding at December 31, 2018 and December 31, 2017, respectively Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Accumulated deficit Retained Earnings (Accumulated Deficit) Total stockholders' equity Total liabilities and stockholders' equity Liabilities and Equity Property, Plant and Equipment [Abstract] Schedule of property and equipment Property, Plant and Equipment [Table Text Block] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Related Party [Axis] Related Party [Axis] Related Party [Domain] Related Party [Domain] Novo A/S Novo [Member] Represents activity related to Novo A/S, a holding company and venture capital provider. Novo Agreement Royalty Agreement Terms [Member] Fovista, Fovista-Related Products, and Other Products Fovista And Related Products And Other Products [Member] Represents information pertaining to Fovista, Fovista-Related Products, and other products as defined by agreement. Agreement Research and Development Arrangement, Contract to Perform for Others [Line Items] Number of tranches in financing Number Of Tranches In Financing The number of tranches in financing. Aggregate royalty rights Aggregate Royalty Guarantees Commitments Amount The amount the entity has committed to make for aggregate future royalty guarantees under agreement. Proceeds from royalty purchase agreement Proceeds from Other Debt Gain on extinguishment of Royalty Purchase Liability Gain On Extinguishment Of Royalty Liability Gain On Extinguishment Of Royalty Liability Summary of Significant Accounting Policies Basis of Presentation and Significant Accounting Policies [Text Block] Common Stock Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Outstanding at beginning of year (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Expired or forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period Outstanding at end of year (in shares) Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Outstanding at beginning of year (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Expired or forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Outstanding at end of year (in dollars per share) Options exercisable at end of year (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Weighted average grant date fair value (per share) of options granted during the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Schedule of future minimum rental commitments under non-cancelable operating leases Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research and development Research and Development Expense [Member] General and administrative General and Administrative Expense [Member] Licensing and Commercialization Agreement Licensing And Commercialization Agreement [Member] Represents information pertaining to the license and commercialization agreement entered into by the entity. Novartis Pharma AG Novartis Pharma A G [Member] Represents information pertaining to Novartis Pharma AG. Achievement of specified patient enrollment milestones Achievement Of Specified Patient Enrollment Milestones [Member] Represents information pertaining to the achievement of specified patient enrollment milestones. License revenue Licensing [Member] Represents information pertaining to licensing activities. Research and development activity revenue Research And Development Activities [Member] Represents information pertaining to the research and development activities. API transfer revenue Active Pharmaceutical Ingredient Transfers [Member] Represents information pertaining to active pharmaceutical ingredient transfers. Joint operating committee revenue Joint Operating Committee Revenue [Member] Represents information pertaining to joint operating committee revenue. Payments for license fees Payments for License Fees Payments for License Fees Upfront fees received Research and Development Arrangement Upfront Fees Received Represents the amount of upfront fees received under the agreement. Patient enrollment-based milestone revenue achieved Research And Development Arrangement Amount Of Enrollment Based Milestone Achieved Represents the amount of patient enrollment-based milestone revenue achieved by the entity. Total collaboration revenue Revenues Schedule of Restructuring and Related Costs [Table] Schedule of Restructuring and Related Costs [Table] Restructuring Type [Axis] Restructuring Type [Axis] Type of Restructuring [Domain] Type of Restructuring [Domain] Severance and other employee costs Employee Severance [Member] Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Restructuring Reserve [Roll Forward] Restructuring Reserve [Roll Forward] Beginning Balance Restructuring Reserve Accrued restructuring expenses Restructuring Charges Payments Payments for Restructuring Ending Balance Deferred tax assets (liabilities) Components of Deferred Tax Assets and Liabilities [Abstract] Deferred revenue Deferred Tax Assets, Deferred Income License and technology payments Deferred Tax Assets License and Technology Payments Amount before allocation of valuation allowances of deferred tax asset attributable to deductible license and technology payments. Share-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Accrued expenses Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals Depreciation, deferred tax liability Deferred Tax Liabilities, Property, Plant and Equipment Depreciation, deferred tax assets Deferred Tax Assets, Property, Plant and Equipment Federal and state net operating loss carryforwards Deferred Tax Assets Operating Loss Carryforwards Federal State And Local Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards, including federal, state and local operating loss carryforwards. Research and development credits Deferred Tax Assets, Tax Credit Carryforwards, Research Other Deferred Tax Assets, Other Deferred income tax assets Deferred Tax Assets, Gross Valuation allowance Deferred Tax Assets, Valuation Allowance Net deferred tax assets Deferred Tax Assets, Net Collaboration revenue Research and development expenses Research and Development Expense General and administrative expenses General and Administrative Expense Income (loss) from operations Operating Income (Loss) Net income (loss) attributable to common stockholders Net Income (Loss) Available to Common Stockholders, Basic Basic (in dollars per share) Dilutive (in dollars per share) Stock Option and Compensation Plans Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Cash Cash Cash equivalents Cash Equivalents, at Carrying Value Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] ESPP Employee Stock [Member] Share-Based Compensation Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Number of shares reserved for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Share-based compensation expense Allocated Share-based Compensation Expense Net Income (Loss) Per Common Share Earnings Per Share [Text Block] Schedule of computation of basic and diluted net income (loss) per common share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of potentially dilutive securities that have been excluded from the computations of diluted weighted average common shares outstanding Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Percent of personnel expected to be effected by reduction in workforce Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date Percent Document And Entity Information Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Document Type Document Type Document Period End Date Document Period End Date Amendment Flag Amendment Flag Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Voluntary Filers Entity Current Reporting Status Entity Current Reporting Status Entity Emerging Growth Company Entity Emerging Growth Company Entity Small Business Entity Small Business Entity Shell Company Entity Shell Company Entity Filer Category Entity Filer Category Entity Public Float Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Summary of the stock option activity including weighted average exercise prices, options outstanding and exercisable Share-based Compensation, Stock Options, Activity [Table Text Block] Summary of the stock options outstanding and exercisable Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block] Schedule of cash proceeds from, and the aggregate intrinsic value of, stock options exercised Cash Proceeds Received and Tax Benefit from Share-based Payment Awards [Table Text Block] Summary of the Company's outstanding shares of RSU awards Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Schedule of assets and liabilities that are measured at fair value on a recurring basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Cash and Cash Equivalents Cash and Cash Equivalents Disclosure [Text Block] Employee Benefit Plan Pension and Other Postretirement Benefits Disclosure [Text Block] Schedule of weighted-average assumptions used to estimate grant date fair value of stock options Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of share-based compensation expense Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Stock Option and Compensation Plans Restricted Stock Units Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Outstanding, beginning of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Awarded (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Outstanding, end of period (in shares) Weighted Average Grant-Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Outstanding, beginning of period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Awarded (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Outstanding, end of period (in dollars per share) Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Domestic Tax Authority Domestic Tax Authority [Member] State and Local Jurisdiction State and Local Jurisdiction [Member] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Tax Cuts and Jobs Act, income tax expense Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit) Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit) Federal net operating loss carryforwards Operating Loss Carryforwards Income tax benefit Tax Adjustments, Settlements, and Unusual Provisions Federal and state tax liability, benefit from income taxes Current Federal, State and Local, Tax Expense (Benefit) Reduction in deferred tax assets and corresponding valuation allowance Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Refund claimed for taxes previously paid Estimated Refund Adjustment from Settlement with Taxing Authority Estimated Refund Adjustment from Settlement with Taxing Authority Estimate of unrecognized tax benefits that may be realized over the next twelve months Significant Change in Unrecognized Tax Benefits is Reasonably Possible, Amount of Unrecorded Benefit Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] 2013 Plan Stock Incentive2013 Plan [Member] Represents information pertaining to the 2013 Stock Incentive Plan. 2007 Plan Stock Incentive2007 Plan [Member] Represents information pertaining to the 2007 Stock Incentive Plan. Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Title of Individual [Axis] Title of Individual [Axis] Relationship to Entity [Domain] Relationship to Entity [Domain] Employees Employees [Member] Represents information pertaining to the employees. Consultants Consultants [Member] Represents information pertaining to the consultants. Non-employee Options Nonemployee Stock Option [Member] An arrangement whereby an non-employees is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Number of shares of common stock available for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Annual increase in shares reserved for issuance under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Annual Increase in Shares Reserved for Issuance Represents the number of shares which will annually increase the shares reserved for issuance under the equity-based compensation plan. Annual increase in shares reserved for issuance under the Plan (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Annual Increase in Shares Reserved for Issuance Represents the percentage of annual increase in the shares reserved for issuance under the equity-based compensation plan. Increase in number of shares available under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Purchase price of common stock as percentage of fair market value Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent Options outstanding (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Weighted-average exercise price of options (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Weighted-average remaining contractual life of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Unrecognized share-based compensation costs for option awards, net of estimated forfeitures Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options Expected weighted average period to recognize share-based compensation costs Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition RSUs expected to vest (in shares) Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest The number of equity-based payment instruments, excluding stock (or unit) options, that are expected to vest in the future as of the reporting date. Weighted-average fair value of RSUs expected to vest (in dollars per share) Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value Represents the weighted average fair value of equity awards, other than options, that are expected to vest as of the reporting date. Aggregate intrinsic value of RSUs expected to vest Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Expected To Vest Intrinsic value of equity-based compensation awards expected to vest. Excludes stock and unit options. Unrecognized compensation costs, net of estimated forfeitures Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options Total fair value vested Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value Common stock issued (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period Proceeds from stock plans Proceeds from Stock Plans Shares issued under ESPP (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Income Statement [Abstract] Operating expenses: Operating Expenses [Abstract] Research and development General and administrative Total operating expenses Operating Expenses Interest income Interest Income (Expense), Nonoperating, Net Other income (expense) Other Nonoperating Income (Expense) Income (loss) before income tax benefit Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Income tax benefit Net income (loss) Net income (loss) per common share: Weighted average common shares outstanding: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Basic (in shares) Dilutive (in shares) Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Manufacturing and clinical equipment Equipment [Member] Computer, software and other office equipment Computer, Software, and Other Office Equipment [Member] Computer, Software, and Other Office Equipment [Member] Property and Equipment Useful life Property and equipment, gross Property, Plant and Equipment, Gross Accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Property and equipment, net Depreciation expense Depreciation Statement of Cash Flows [Abstract] Operating Activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Adjustments to reconcile net loss to net cash (used in) provided by operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation Amortization of premium and discounts on investment securities Investment Income, Net, Amortization of Discount and Premium Non-cash charge on acquired in-process research and development Asset Impairment Charges, Excluding Transaction Costs Asset Impairment Charges, Excluding Transaction Costs Non-cash gain on extinguishment of royalty purchase agreement Deferred income taxes Deferred Income Taxes and Tax Credits Share-based compensation Share-based Compensation Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Income tax receivable Increase (Decrease) in Income Taxes Receivable Due from Novartis Pharma AG Increase (Decrease) in Contract with Customer, Asset Prepaid expense and other current assets Increase (Decrease) in Prepaid Expense and Other Current Assets The increase (decrease) during the reporting period in the value of prepaid expenses and other current assets not separately disclosed in the statement of cash flows. Accrued interest receivable Increase (Decrease) in Accrued Interest Receivable, Net Other assets Increase (Decrease) in Other Noncurrent Assets Accrued research and development expenses Increase Decrease in Accrued research and development Represents the increase (decrease) during the reporting period in the aggregate amount of research and development expenses incurred. Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable and Accrued Liabilities Deferred revenue Increase (Decrease) in Contract with Customer, Liability Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Investing Activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Purchase of marketable securities Payments to Acquire Marketable Securities Maturities of marketable securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Purchase of property and equipment Payments to Acquire Property, Plant, and Equipment Net cash provided by investing activities Net Cash Provided by (Used in) Investing Activities Financing Activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Proceeds from issuance of common stock related to acquisition Proceeds from Issuance of Common Stock Proceeds from employee stock plan purchases and stock option exercises Proceeds From Stock Options And Warrants Exercised The cash inflow from associated with the amount received from holders exercising their stock options and warrants. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net change in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value [Abstract] Beginning of period End of period Supplemental disclosure of cash paid Supplemental Disclosure of Cash Paid [Abstract] Income taxes received, net Income Taxes Paid, Net Supplemental disclosures of non-cash information related to investing activities Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Change in unrealized gain (loss) on available for sale securities, net of tax Common stock issued to acquire net assets of Inception 4, Inc. Stock Issued Licensing and Commercialization Agreement Collaborative Arrangement Disclosure [Text Block] Operating Leases Leases of Lessee Disclosure [Text Block] Property and Equipment Property, Plant and Equipment Disclosure [Text Block]