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  <xsd:element abstract="true" id="opht_ArchemixCorpMember" name="ArchemixCorpMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_AssetAcquisitionAxis" name="AssetAcquisitionAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_AssetAcquisitionClinicalAndMarketingApprovalMilestones" name="AssetAcquisitionClinicalAndMarketingApprovalMilestones" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="opht_AssetAcquisitionContingentConsiderationArrangementsContingentlyIssuableSharesAsAPercentageOfSharesOutstanding" name="AssetAcquisitionContingentConsiderationArrangementsContingentlyIssuableSharesAsAPercentageOfSharesOutstanding" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesSharesIssuableHigh" name="AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesSharesIssuableHigh" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="opht_AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesValueHigh" name="AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesValueHigh" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="opht_AssetAcquisitionDomain" name="AssetAcquisitionDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_BEST1LicenseAgreementMember" name="BEST1LicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_C5LicensedProductsMember" name="C5LicensedProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_ConcentrationOfSuppliersPolicyPolicyTextBlock" name="ConcentrationOfSuppliersPolicyPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_EmployeeAndNonemployeeStockOptionMember" name="EmployeeAndNonemployeeStockOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_FirstIndicationMember" name="FirstIndicationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_GAProductMember" name="GAProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_Inception4Member" name="Inception4Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_IncomeStatementandStatementofComprehensiveIncomeAbstractAbstract" name="IncomeStatementandStatementofComprehensiveIncomeAbstractAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_IncreaseDecreaseInAccruedResearchAndDevelopment" name="IncreaseDecreaseInAccruedResearchAndDevelopment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="opht_IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" name="IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_MilestoneEventsAxis" name="MilestoneEventsAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_MilestoneEventsDomain" name="MilestoneEventsDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_NumberofLicensedProducts" name="NumberofLicensedProducts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_OtherLicensedProductMember" name="OtherLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_PaymentsforLicenseFees" name="PaymentsforLicenseFees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_PrimaryLicensedProductMember" name="PrimaryLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_ProceedsFromStockOptionsAndWarrantsExercised" name="ProceedsFromStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_RHOadRPLicenseAgreementMember" name="RHOadRPLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_ScheduleOfCommitmentsAndContingenciesTable" name="ScheduleOfCommitmentsAndContingenciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_ScheduleofCompensationCostforSharebasedPaymentArrangementsAllocationofSharebasedCompensationCostsbyFinancialStatementLineTableTextBlock" name="ScheduleofCompensationCostforSharebasedPaymentArrangementsAllocationofSharebasedCompensationCostsbyFinancialStatementLineTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_SecondandThirdIndicationMember" name="SecondandThirdIndicationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="instant" />
  <xsd:element id="opht_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAnnualIncreaseInSharesReservedForIssuance" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAnnualIncreaseInSharesReservedForIssuance" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_ShareBasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestNumber" name="ShareBasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="opht_ShareBasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesAvailableForFuturePurchase" name="ShareBasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesAvailableForFuturePurchase" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="opht_SpecifiedClinicalMarketingApprovalandReimbursementApprovalMilestonesRelatedtoaLicensedProductMember" name="SpecifiedClinicalMarketingApprovalandReimbursementApprovalMilestonesRelatedtoaLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_SpecifiedCommercialSalesMilestonesRelatedtoaLicensedProductMember" name="SpecifiedCommercialSalesMilestonesRelatedtoaLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_StockIncentive2013PlanMember" name="StockIncentive2013PlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_StockIssuedDuringPeriodSharesOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodSharesOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="opht_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_SupplementalDisclosureOfCashPaidAbstract" name="SupplementalDisclosureOfCashPaidAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_SustainedDeliveryApplicationsMember" name="SustainedDeliveryApplicationsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_UniversityOfFloridaResearchFoundationUFRFAndUniversityOfPennsylvaniaPennMember" name="UniversityOfFloridaResearchFoundationUFRFAndUniversityOfPennsylvaniaPennMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_UniversityofFloridaResearchFoundationUFRFMember" name="UniversityofFloridaResearchFoundationUFRFMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="opht_WetAMDProductMember" name="WetAMDProductMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
