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  <xs:element id="opht_AssetAcquisitionEquityInterestIssuedOrIssuableNumberOfShares" abstract="false" name="AssetAcquisitionEquityInterestIssuedOrIssuableNumberOfShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="opht_PrimaryLicensedProductMember" abstract="true" name="PrimaryLicensedProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_SharesIssuedForLicenseFees" abstract="false" name="SharesIssuedForLicenseFees" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="opht_PaymentsForLicenseFees" abstract="false" name="PaymentsForLicenseFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_ProceedsFromStockOptionsAndWarrantsExercised" abstract="false" name="ProceedsFromStockOptionsAndWarrantsExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSale" abstract="false" name="CashAndCashEquivalentsAndDebtSecuritiesAvailableForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_EmployeesMember" abstract="true" name="EmployeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_AccumulatedOtherComprehensiveIncomeRollForward" abstract="true" name="AccumulatedOtherComprehensiveIncomeRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="opht_AssetAcquisitionTextBlock" abstract="false" name="AssetAcquisitionTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="opht_ScheduleOfAssetAcquisitionTable" abstract="true" name="ScheduleOfAssetAcquisitionTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="opht_SpecifiedCommercialSalesMilestonesRelatedtoaLicensedProductMember" abstract="true" name="SpecifiedCommercialSalesMilestonesRelatedtoaLicensedProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_AchievementOfSpecifiedCommercialMilestonesMember" abstract="true" name="AchievementOfSpecifiedCommercialMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_SpecifiedClinicalMarketingApprovalandReimbursementApprovalMilestonesRelatedtoaLicensedProductMember" abstract="true" name="SpecifiedClinicalMarketingApprovalandReimbursementApprovalMilestonesRelatedtoaLicensedProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_FovistaAndRelatedProductsAndOtherProductsMember" abstract="true" name="FovistaAndRelatedProductsAndOtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_DeferredTaxLiabilitiesRightOfUseAsset" abstract="false" name="DeferredTaxLiabilitiesRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_ExercisePriceRangeFiveMember" abstract="true" name="ExercisePriceRangeFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_NonemployeeStockOptionMember" abstract="true" name="NonemployeeStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_ConcentrationOfSuppliersPolicyPolicyTextBlock" abstract="false" name="ConcentrationOfSuppliersPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="opht_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOptionsExercisableAbstract" abstract="true" name="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOptionsExercisableAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="opht_DeferredTaxAssetsOperatingLossCarryforwardsFederalStateAndLocal" abstract="false" name="DeferredTaxAssetsOperatingLossCarryforwardsFederalStateAndLocal" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_StockIncentive2013PlanMember" abstract="true" name="StockIncentive2013PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVest" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVest" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="opht_ExercisePriceRangeOneMember" abstract="true" name="ExercisePriceRangeOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_ExercisePriceRangeThreeMember" abstract="true" name="ExercisePriceRangeThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="opht_DeferredTaxAssetsLeaseObligation" abstract="false" name="DeferredTaxAssetsLeaseObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesValueHigh" abstract="false" name="AssetAcquisitionContingentConsiderationArrangementsRangeOfOutcomesValueHigh" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="opht_AssetAcquisitionConsiderationTransferredEquityInterestsIssuedAndIssuable" abstract="false" name="AssetAcquisitionConsiderationTransferredEquityInterestsIssuedAndIssuable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
