<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:5a0753f3-e1fa-411f-9504-48143c91756d,g:fd183f0b-ecc5-4e20-8dc6-8e5d928d9191-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.ophthotech.com/role/Cover" xlink:type="simple" xlink:href="opht-20200630.xsd#Cover"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/Cover" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/UnauditedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="opht-20200630.xsd#UnauditedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/UnauditedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_2e03846d-c98a-4042-b37f-f89358f9e208" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c2bf3203-2216-4cfc-be87-d2bca257919b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_2e03846d-c98a-4042-b37f-f89358f9e208" xlink:to="loc_us-gaap_Liabilities_c2bf3203-2216-4cfc-be87-d2bca257919b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4c851f85-0fe6-4c5f-87d6-de2b232b108d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_2e03846d-c98a-4042-b37f-f89358f9e208" xlink:to="loc_us-gaap_StockholdersEquity_4c851f85-0fe6-4c5f-87d6-de2b232b108d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d8ad5974-f144-4db9-a49e-85f03ac55698" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_250cf6e8-1368-441f-82b7-10712f004bcc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8ad5974-f144-4db9-a49e-85f03ac55698" xlink:to="loc_us-gaap_PreferredStockValue_250cf6e8-1368-441f-82b7-10712f004bcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_698d6309-f3f3-4463-94e8-e65687403455" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8ad5974-f144-4db9-a49e-85f03ac55698" xlink:to="loc_us-gaap_CommonStockValue_698d6309-f3f3-4463-94e8-e65687403455" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_d134862b-9f74-4ccf-b318-6e18764d95c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8ad5974-f144-4db9-a49e-85f03ac55698" xlink:to="loc_us-gaap_AdditionalPaidInCapital_d134862b-9f74-4ccf-b318-6e18764d95c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9a6ea5ed-cb05-4a49-b4bc-4f6ba4809938" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d8ad5974-f144-4db9-a49e-85f03ac55698" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9a6ea5ed-cb05-4a49-b4bc-4f6ba4809938" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_869463ba-6ed7-48aa-92ac-06dc9c38c274" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_opht_AccruedResearchAndDevelopment_065f89fe-47c3-4707-a0f4-5e77d5a44186" xlink:href="opht-20200630.xsd#opht_AccruedResearchAndDevelopment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_869463ba-6ed7-48aa-92ac-06dc9c38c274" xlink:to="loc_opht_AccruedResearchAndDevelopment_065f89fe-47c3-4707-a0f4-5e77d5a44186" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_3890ebcb-b2d6-463f-b193-61766fc1e7c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_869463ba-6ed7-48aa-92ac-06dc9c38c274" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_3890ebcb-b2d6-463f-b193-61766fc1e7c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_b519f4fb-3f5e-46f3-936e-d5f29506ff8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_869463ba-6ed7-48aa-92ac-06dc9c38c274" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_b519f4fb-3f5e-46f3-936e-d5f29506ff8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_0f4448e2-7570-4c26-a77c-068777473022" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_d2d93404-dea2-47b6-8990-95cc6461685a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0f4448e2-7570-4c26-a77c-068777473022" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_d2d93404-dea2-47b6-8990-95cc6461685a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_e0912e03-1d1a-44d5-8505-1fcd6e7c4aaf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0f4448e2-7570-4c26-a77c-068777473022" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_e0912e03-1d1a-44d5-8505-1fcd6e7c4aaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_87e09f89-8935-432d-af22-3a276b80556b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0f4448e2-7570-4c26-a77c-068777473022" xlink:to="loc_us-gaap_IncomeTaxesReceivable_87e09f89-8935-432d-af22-3a276b80556b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a9b2c1c5-fa49-4aea-8e52-736b190b1a22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:to="loc_us-gaap_AssetsCurrent_a9b2c1c5-fa49-4aea-8e52-736b190b1a22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_b5aef591-2680-412c-a9f7-c36653e7aca5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_b5aef591-2680-412c-a9f7-c36653e7aca5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_79e63428-51cf-4cac-afbb-03d253604e62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_79e63428-51cf-4cac-afbb-03d253604e62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivableNoncurrent_63dcca52-eb39-4707-a9f6-f0743c3ca8b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxesReceivableNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:to="loc_us-gaap_IncomeTaxesReceivableNoncurrent_63dcca52-eb39-4707-a9f6-f0743c3ca8b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_699b558d-06c8-411e-ac00-9134f05458d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3c807a81-9bf2-43c1-9f10-79fe73b0ca49" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_699b558d-06c8-411e-ac00-9134f05458d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9e685efd-56aa-4b95-89d0-4bae0dd8fb90" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_a5403983-a592-4458-95c2-ad87e932e766" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9e685efd-56aa-4b95-89d0-4bae0dd8fb90" xlink:to="loc_us-gaap_LiabilitiesCurrent_a5403983-a592-4458-95c2-ad87e932e766" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_8b2e10cc-2bbf-4193-99b3-c22ae45d6339" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9e685efd-56aa-4b95-89d0-4bae0dd8fb90" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_8b2e10cc-2bbf-4193-99b3-c22ae45d6339" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ophthotech.com/role/UnauditedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="opht-20200630.xsd#UnauditedConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/UnauditedConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="opht-20200630.xsd#UnauditedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_ddfea643-5b98-433b-8753-4b6abe271699" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_bd670dc9-dfd2-4858-89e8-d2e6176b6251" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_ddfea643-5b98-433b-8753-4b6abe271699" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_bd670dc9-dfd2-4858-89e8-d2e6176b6251" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_2e8a8e40-e52c-4ac0-93d2-94431e9a558b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_ddfea643-5b98-433b-8753-4b6abe271699" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_2e8a8e40-e52c-4ac0-93d2-94431e9a558b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d8f81fa4-73a8-4d4c-8ea6-1f67a1dbf4a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_53997347-49e2-4b75-9bf7-d5d8bd198b76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d8f81fa4-73a8-4d4c-8ea6-1f67a1dbf4a9" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_53997347-49e2-4b75-9bf7-d5d8bd198b76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_53479ef3-b435-44b2-95b7-f5cef7fe20d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d8f81fa4-73a8-4d4c-8ea6-1f67a1dbf4a9" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_53479ef3-b435-44b2-95b7-f5cef7fe20d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01e0ceea-3c9e-4228-bc26-638bcfedb0f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_26a0e31d-1226-4a29-9c84-4106c7884559" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_01e0ceea-3c9e-4228-bc26-638bcfedb0f4" xlink:to="loc_us-gaap_OperatingExpenses_26a0e31d-1226-4a29-9c84-4106c7884559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4d002056-f82d-4c6f-ae12-4c53d5f4fff0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_aba9f86f-c851-459b-9ecb-bb2a5404ac83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4d002056-f82d-4c6f-ae12-4c53d5f4fff0" xlink:to="loc_us-gaap_OperatingIncomeLoss_aba9f86f-c851-459b-9ecb-bb2a5404ac83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_65d08ad4-cfc4-4858-b450-2428024c0fe7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4d002056-f82d-4c6f-ae12-4c53d5f4fff0" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_65d08ad4-cfc4-4858-b450-2428024c0fe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_bff8c7ca-0fb2-4c32-92e4-e881c12850a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4d002056-f82d-4c6f-ae12-4c53d5f4fff0" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_bff8c7ca-0fb2-4c32-92e4-e881c12850a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d332b2a7-42af-42b6-9a83-62adbae2579c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d508723d-1e9d-4be1-bf13-eb70bf8d1ac6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_d332b2a7-42af-42b6-9a83-62adbae2579c" xlink:to="loc_us-gaap_NetIncomeLoss_d508723d-1e9d-4be1-bf13-eb70bf8d1ac6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="opht-20200630.xsd#UnauditedConsolidatedStatementsofStockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofStockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="opht-20200630.xsd#UnauditedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/UnauditedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c004c59e-c724-4aa5-9c3c-cc6e363c3c40" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c004c59e-c724-4aa5-9c3c-cc6e363c3c40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_24e82a19-7d3d-4246-a64e-59018f388733" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_NetIncomeLoss_24e82a19-7d3d-4246-a64e-59018f388733" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInIncomeTaxesReceivable_f25a4071-7f06-4d63-8759-c4bb526778ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInIncomeTaxesReceivable"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_IncreaseDecreaseInIncomeTaxesReceivable_f25a4071-7f06-4d63-8759-c4bb526778ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_91e26c95-50e5-453a-910d-664ba0f6fa76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_91e26c95-50e5-453a-910d-664ba0f6fa76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_c942e287-4e77-43c4-b325-3c5e8e5ee293" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_Depreciation_c942e287-4e77-43c4-b325-3c5e8e5ee293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_f6262ad7-a53b-4e26-815f-a065b8e70934" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_ShareBasedCompensation_f6262ad7-a53b-4e26-815f-a065b8e70934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_opht_IncreaseDecreaseInAccruedResearchAndDevelopment_f4830f2a-8681-4acd-9f66-1228777f703b" xlink:href="opht-20200630.xsd#opht_IncreaseDecreaseInAccruedResearchAndDevelopment"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_opht_IncreaseDecreaseInAccruedResearchAndDevelopment_f4830f2a-8681-4acd-9f66-1228777f703b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_b947b076-c80a-4b63-8d9f-693ddf6e91a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_b947b076-c80a-4b63-8d9f-693ddf6e91a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_49140db8-25cd-4d70-8cca-0667f379b718" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_99279c68-4103-4913-8e81-b23c4e154a6b" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_49140db8-25cd-4d70-8cca-0667f379b718" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9e3471a-1150-489f-83cf-8800167eb9bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_59e87fbb-facf-4681-9fa5-ac3816307357" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9e3471a-1150-489f-83cf-8800167eb9bf" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_59e87fbb-facf-4681-9fa5-ac3816307357" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_opht_ProceedsFromStockOptionsAndWarrantsExercised_8a07971e-7f20-416f-a3ba-8c1c8ee0d9ae" xlink:href="opht-20200630.xsd#opht_ProceedsFromStockOptionsAndWarrantsExercised"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a9e3471a-1150-489f-83cf-8800167eb9bf" xlink:to="loc_opht_ProceedsFromStockOptionsAndWarrantsExercised_8a07971e-7f20-416f-a3ba-8c1c8ee0d9ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c55679a9-5510-4a23-8c3f-a5711cd0e18a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7a499b99-556d-4def-acff-cae5bd76188d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c55679a9-5510-4a23-8c3f-a5711cd0e18a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7a499b99-556d-4def-acff-cae5bd76188d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5305aeac-556c-48a7-bad0-5de152308425" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c55679a9-5510-4a23-8c3f-a5711cd0e18a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5305aeac-556c-48a7-bad0-5de152308425" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1e55be3e-d78f-43a8-a705-00f074beab08" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c55679a9-5510-4a23-8c3f-a5711cd0e18a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1e55be3e-d78f-43a8-a705-00f074beab08" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ophthotech.com/role/Business" xlink:type="simple" xlink:href="opht-20200630.xsd#Business"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/Business" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/BusinessNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#BusinessNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/BusinessNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesSegmentandGeographicInformationDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesSegmentandGeographicInformationDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesSegmentandGeographicInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesCashandCashEquivalentsDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesCashandCashEquivalentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesShareBasedCompensationDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesShareBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesShareBasedCompensationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesScheduleofWeightedAverageAssumptionsDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#SummaryofSignificantAccountingPoliciesScheduleofWeightedAverageAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/SummaryofSignificantAccountingPoliciesScheduleofWeightedAverageAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CommonStock" xlink:type="simple" xlink:href="opht-20200630.xsd#CommonStock"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CommonStock" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CommonStockDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#CommonStockDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CommonStockDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/NetLossPerCommonShare" xlink:type="simple" xlink:href="opht-20200630.xsd#NetLossPerCommonShare"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/NetLossPerCommonShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/NetLossPerCommonShareTables" xlink:type="simple" xlink:href="opht-20200630.xsd#NetLossPerCommonShareTables"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/NetLossPerCommonShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/NetLossPerCommonShareNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#NetLossPerCommonShareNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/NetLossPerCommonShareNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/NetLossPerCommonShareDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#NetLossPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/NetLossPerCommonShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CashandCashEquivalents" xlink:type="simple" xlink:href="opht-20200630.xsd#CashandCashEquivalents"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CashandCashEquivalents" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CashandCashEquivalentsNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#CashandCashEquivalentsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CashandCashEquivalentsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensation" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensation"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationTables" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofShareBasedCompensationExpensebyAwardTypeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationSummaryofShareBasedCompensationExpensebyAwardTypeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofShareBasedCompensationExpensebyAwardTypeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofShareBasedCompensationExpensebyFinancialStatementLineDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationSummaryofShareBasedCompensationExpensebyFinancialStatementLineDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofShareBasedCompensationExpensebyFinancialStatementLineDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofStockOptionActivityDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationSummaryofStockOptionActivityDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofStockOptionActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofOutstandingRSUAwardsGrantedDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#ShareBasedCompensationSummaryofOutstandingRSUAwardsGrantedDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/ShareBasedCompensationSummaryofOutstandingRSUAwardsGrantedDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/IncomeTaxes" xlink:type="simple" xlink:href="opht-20200630.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#IncomeTaxesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="opht-20200630.xsd#FairValueMeasurements"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/FairValueMeasurements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="opht-20200630.xsd#FairValueMeasurementsTables"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="opht-20200630.xsd#CommitmentsandContingencies"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CommitmentsandContingencies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ophthotech.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="opht-20200630.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ophthotech.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended"/>
</link:linkbase>
