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  <xs:element id="isee_ShareBasedCompensationArrangementsByShareBasedPaymentAwardWithholdingPeriod" abstract="false" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardWithholdingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="isee_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOptionsOutstandingAbstract" abstract="true" name="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOptionsOutstandingAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="isee_MiniCEP290Member" abstract="true" name="MiniCEP290Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="isee_UniversityofFloridaResearchFoundationUFRFMember" abstract="true" name="UniversityofFloridaResearchFoundationUFRFMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="isee_UnderwrittenOfferingMember" abstract="true" name="UnderwrittenOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="isee_EmployeesMember" abstract="true" name="EmployeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isee_PrivatePlacementUnderwritersMember" abstract="true" name="PrivatePlacementUnderwritersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isee_DocumentAndEntityInformationAbstract" abstract="true" name="DocumentAndEntityInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
</xs:schema>
